Ethionamide → HCID 22249370, compound

HRID 887539Notes

Reaction equation

HRID 887539 reaction equation
[CH3:1][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=S)[CH:6]=[CH:5][N:4]=1>CO.[Ni]>[CH2:2]([C:3]1[CH:8]=[C:7]([CH2:9][NH2:11])[CH:6]=[CH:5][N:4]=1)[CH3:1]

Participants

4

Reactant 1

HCID 2761171Ethionamide

Product 1

HCID 22249370HCID 22249370, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-ethyl-4-thiopyridylamide (10 g) in MeOH (250 ml) was added Raney 2800 Nickel (5 g, Aldrich) in one portion. The mixture was stirred at RT for 2 days then at 60° C. for 16 h. The mixture was filtered, concentrated to provide the desired compound.

Workup

  1. waitat 60° C. for 16 h
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-32dabe87641849c5ac32f6c75c2c0847
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

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