Sulfuric Acid → 2-Bromo-1-tert-butyl-4-nitrobenzene

HRID 887586Notes

Reaction equation

HRID 887586 reaction equation
[Br:1]Br.[C:3]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)([CH3:6])([CH3:5])[CH3:4].OS(O)(=O)=O>S([O-])([O-])(=O)=O.[Ag+2].O>[C:3]([C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:8]=1[Br:1])([CH3:6])([CH3:4])[CH3:5]

Participants

6

Reactant 3

HCID 1118Sulfuric AcidHCID 24408BromineHCID 767731-tert-Butyl-4-nitrobenzene

Product 1

HCID 2385872-Bromo-1-tert-butyl-4-nitrobenzene

Reagents, catalysts & solvents 2

HCID 178418844HCID 178418844, compoundCatalystHCID 962WaterSolvent

Procedure

Bromine (17.4 ml) was added dropwise over 40 min to a stirred mixture of 4-tert-butylnitrobenzene (59.5 g, 332 mmol), silver(II) sulfate (56.5 g, 181 mmol), H2SO4 (300 ml), and H2O (33 ml) at RT. The mixture was stirred for a further 3 h and then poured into 0.1 M Na2S2O5/H2O (1 L)

Sources & evidence

ORD record
ord-04ef3a87ad9a47e799ebc1de91b6cd08
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

Loading…