Methanol → 6-Amino-3,4-dihydroquinazolin-4-one

HRID 887594Notes

Reaction equation

HRID 887594 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][NH:8][C:7]2=[O:14])([O-])=O.CO>CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][NH:8][C:7]2=[O:14]

Participants

5

Reactant 2

HCID 887MethanolHCID 1353985026-Nitro-3,4-dihydroquinazolin-4-one

Product 1

HCID 1354780376-Amino-3,4-dihydroquinazolin-4-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenation of 6-nitro-3H-quinazolin-4-one (2 g) in EtOH (200 mL) was catalyzed by Pd/c (10%, 200 mg) under a H2 balloon for 1 h. MeOH (200 mL) was added to the mixture. The suspension was filtered through a layer of Celite® and the filtrate was concentrated in vacuum to give the desired compound.

Workup

  1. customfor 1 h
  2. filtrationThe suspension was filtered through a layer of Celite®
  3. concentrationthe filtrate was concentrated in vacuum

Sources & evidence

ORD record
ord-3a028a2750ab44bfb97c8f51b572de71
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

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