HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 6-Amino-3,4-dihydroquinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 6-Nitro-3,4-dihydroquinazolin-4-one | HCID 135398502 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Amino-3,4-dihydroquinazolin-4-one | HCID 135478037 | — |
Reaction Steps
Hydrogenation of 6-nitro-3H-quinazolin-4-one (2 g) in EtOH (200 mL) was catalyzed by Pd/c (10%, 200 mg) under a H2 balloon for 1 h. MeOH (200 mL) was added to the mixture. The suspension was filtered through a layer of Celite® and the filtrate was concentrated in vacuum to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247430B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-3a028a2750ab44bfb97c8f51b572de71 |
| Source note | uspto-grants-2012_08 |