反应详情

To a solution of 2-amino-6-bromopyridine (3.015 g, 0.017 mol) and Et3N (2.40 mL, 0.017 mol) in CH2Cl2 (20.0 mL), was added 3,3-dimethylacryloylchloride (1.96 mL, 0.017 mol) under N2 at 0° C. The mixture was slowly warmed to RT and stirred for 12 h. The reaction was quenched by the addition of H2O (20.0 mL), the organic layer was separated, dried over Na2SO4 and evaporated to dryness to yield crude compound which was used without purification.

1. customThe reaction was quenched by the addition of H2O (20.0 mL)
2. customthe organic layer was separated
3. dry with materialdried over Na2SO4
4. customevaporated to dryness
5. customto yield crude compound which
6. customwas used without purification