Hydrochloric Acid → N-(benzo[d]thiazol-2-yl)-2-(4-chloro-5-formylthiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide

HRID 88760Notes

Reaction equation

HRID 88760 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[Cl:25][c:26]1[s:27][c:28]([CH:32]=[O:33])[c:29]([Cl:31])[n:30]1.[ClH:1].[ClH:2].[Cs+:38].[Cs+:39].[OH2:40].[s:3]1[c:4]([NH:12][C:13](=[O:14])[c:15]2[cH:16][cH:17][cH:18][c:19]3[c:24]2[CH2:23][NH:22][CH2:21][CH2:20]3)[n:5][c:6]2[c:7]1[cH:8][cH:9][cH:10][cH:11]2>>[s:3]1[c:4]([NH:12][C:13](=[O:14])[c:15]2[cH:16][cH:17][cH:18][c:19]3[c:24]2[CH2:23][N:22]([c:26]2[s:27][c:28]([CH:32]=[O:33])[c:29]([Cl:31])[n:30]2)[CH2:21][CH2:20]3)[n:5][c:6]2[c:7]1[cH:8][cH:9][cH:10][cH:11]2

Participants

7

Reactant 6

HCID 313Hydrochloric Acid2×HCID 962WaterHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 14886722,4-Dichloro-1,3-thiazole-5-carboxaldehydeHCID 59447456N-(Benzo[d]thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide

Product 1

HCID 59447544N-(benzo[d]thiazol-2-yl)-2-(4-chloro-5-formylthiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-8-carboxamide

Sources & evidence

ORD record
ord-64b1ed79eb4046568ea83c78ecd302e7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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