Triethylamine → HCID 86588704, compound

HRID 887605Notes

Reaction equation

HRID 887605 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([NH:18][C:19](=[O:27])[C:20]2[CH:25]=[CH:24][CH:23]=[N:22][C:21]=2[Cl:26])[CH:8]=[CH:9][C:10]=1[C:11]([F:17])([F:16])[C:12]([F:15])([F:14])[F:13].CCN(CC)CC.[CH3:35][S:36](Cl)(=[O:38])=[O:37]>C(Cl)Cl>[Cl:26][C:21]1[N:22]=[CH:23][CH:24]=[CH:25][C:20]=1[C:19]([NH:18][C:7]1[CH:8]=[CH:9][C:10]([C:11]([F:16])([F:17])[C:12]([F:15])([F:14])[F:13])=[C:5]([O:4][CH2:3][CH2:2][NH:1][S:36]([CH3:35])(=[O:38])=[O:37])[CH:6]=1)=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 21961390HCID 21961390, compound

Product 1

HCID 86588704HCID 86588704, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 381 mg (0.93 mmol) N-[3-(2-amino-ethoxy)-4-pentafluoroethyl-phenyl]-2-chloro-nicotinamide in 10 ml CH2Cl2 at 0° C. was added 0.389 ml Et3N and 0.072 ml (0.93 mmol) methanesulfonylchloride. After 5 min, the reaction was stirred at RT for 30 min. The reaction was diluted with CH2Cl2, washed with brine, dried over Na2SO4, filtered, concentrated, and dried under vacuum, yielding the titled compound as a white foamy solid.

Workup

  1. washwashed with brine
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customdried under vacuum

Sources & evidence

ORD record
ord-47a47f1f8478443bb2a3c12a86875229
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

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