HCID 68533040, compound → HCID 68910708, compound

HRID 887615Notes

Reaction equation

HRID 887615 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH:10]=[C:9]([C:12]([CH3:23])([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[CH3:13])[CH2:8][CH2:7]1)=[O:5])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH:8]=[C:9]([C:12]([CH3:13])([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=2)[CH3:23])[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 68533040HCID 68533040, compound

Product 1

HCID 68910708HCID 68910708, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-[1-Methyl-1-(4-nitro-phenyl)-ethyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester was dissolved in EtOH (150 mL) and suspended with Pd/C (10%, 1 g). The reaction flask was equipped with a balloon filled with H2. The hydrogenation was continued for 3 days. The mixture was filtered through a layer of Celite® and concentrated in vacuo to provide the desired compound as a light brown oil.

Workup

  1. customThe reaction flask was equipped with a balloon
  2. additionfilled with H2
  3. filtrationThe mixture was filtered through a layer of Celite®
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-26ddee1dd3e140739f5b2d0bdc93368f
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

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