(4-Aminomethyl-pyridin-2-yl)-(4-methoxy-benzyl)-amine → 4-(Aminomethyl)pyridin-2-amine

Participants

Reaction Steps

(4-Aminomethyl-pyridin-2-yl)-(4-methoxy-benzyl)-amine (12 g, 50 mmole) was dissolved in TFA (150 mL) and heated to reflux for 1 h. After cooling, the reaction mixture was concentrated in vacuum and the residue was partitioned between HCl (1N, aq.) and EtOAc. The aqueous layer was washed with EtOAc then hexanes and concentrated to dryness in vacuum to give an off white solid as a dihydrochloric salt.

Provenance & Evidence