反应详情

(4-Aminomethyl-pyridin-2-yl)-(4-methoxy-benzyl)-amine (12 g, 50 mmole) was dissolved in TFA (150 mL) and heated to reflux for 1 h. After cooling, the reaction mixture was concentrated in vacuum and the residue was partitioned between HCl (1N, aq.) and EtOAc. The aqueous layer was washed with EtOAc then hexanes and concentrated to dryness in vacuum to give an off white solid as a dihydrochloric salt.

1. temperatureheated
2. temperatureto reflux for 1 h
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated in vacuum
5. customthe residue was partitioned between HCl (1N, aq.) and EtOAc
6. washThe aqueous layer was washed with EtOAc
7. concentrationhexanes and concentrated to dryness in vacuum
8. customto give an off white solid as a dihydrochloric salt