Triethylamine → HCID 21961454, compound

HRID 887651Notes

Reaction equation

HRID 887651 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][N:9]=1)C#N.C[CH2:11][N:12](CC)CC>[Pd].CCO>[NH2:1][C:2]1[CH:3]=[C:4]([NH:12][CH3:11])[CH:7]=[CH:8][N:9]=1

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 70155242-Aminoisonicotinonitrile

Product 1

HCID 21961454HCID 21961454, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixture of 2-aminoisonicotinonitrile (0.043 mol) and Pd/C (10%, 6.00 g) was added Et3N (40.0 mL) and EtOH (160.0 mL) in a parr bottle and hydrogenated at 50 psi for 12 h. Crude mixture was filtered through Celite®, concentrated under vacuo and dried under high vacuum to yield compound.

Workup

  1. filtrationCrude mixture was filtered through Celite®
  2. concentrationconcentrated under vacuo
  3. customdried under high vacuum
  4. customto yield compound

Sources & evidence

ORD record
ord-e50ac7fbfc444d57b40de725e3c4eee4
Source dataset
uspto-grants-2012_08
Patent number
US08247430B2

Reaction notes

Loading…