Potassium Hydroxide → HCID 178493337, compound

HRID 887683Notes

Reaction equation

HRID 887683 reaction equation
[OH:1][C:2]1[C:11]2[C:10](=[O:12])[C:9]([O:13][CH3:14])=[CH:8][C:7](=[O:15])[C:6]=2[C:5]([OH:16])=[C:4]2[C:17](=[O:38])[C@:18]3([C:32]4[C:31]([OH:33])=[C:30]5[C:25]([CH:26]=[C:27]([C:35]([OH:37])=[O:36])[NH:28][C:29]5=[O:34])=[CH:24][C:23]=4[CH2:22][CH2:21]3)[C:19](=[O:20])[C:3]=12.[OH-].[K+:40]>CN(C=O)C>[OH:1][C:2]1[C:11]2[C:10](=[O:12])[C:9]([O:13][CH3:14])=[CH:8][C:7](=[O:15])[C:6]=2[C:5]([OH:16])=[C:4]2[C:17](=[O:38])[C@:18]3([C:32]4[C:31]([OH:33])=[C:30]5[C:25]([CH:26]=[C:27]([C:35]([O-:37])=[O:36])[NH:28][C:29]5=[O:34])=[CH:24][C:23]=4[CH2:22][CH2:21]3)[C:19](=[O:20])[C:3]=12.[K+:40]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178493336HCID 178493336, compound

Product 1

HCID 178493337HCID 178493337, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6.9 mg (13.3 μmol) Fredericamycin carboxylic acid (12) are dissolved in 5 mL DMF under nitrogen. At room temperature and under oxygen exclusion and vigorous stirring, 1.27 mL (12.7 μmol) of an aqueous 0.01 N KOH solution is added dropwise. It is stirred for 15 minutes at room temperature, and concentrated in high vacuum until dry.

Workup

  1. concentrationconcentrated in high vacuum
  2. customuntil dry

Sources & evidence

ORD record
ord-f00a13507844488987472c788d204243
Source dataset
uspto-grants-2012_08
Patent number
US08247424B2

Reaction notes

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