4-(Aminomethyl)piperidine → HCID 178442044, compound

HRID 887687Notes

Reaction equation

HRID 887687 reaction equation
OC1C2C(=O)C(OC)=CC(=O)C=2C(O)=C2C(=O)[C@]3(C4C(O)=C5C(C=C(/C=N/O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)NC5=O)=CC=4CC3)C(=O)C=12.[CH3:50]/[CH:51]=[CH:52]/[CH:53]=[CH:54]/[C:55]1[NH:65][C:63](=[O:64])[C:62]2[C:57](=[CH:58][C:59]3[CH2:69][CH2:68][C:67]4([C:78](=[O:79])[C:77]5[C:72](=[C:73]([OH:89])[C:74]6[C:85](=[O:86])[CH:84]=[C:83](OC)[C:81](=[O:82])[C:75]=6[C:76]=5[OH:80])[C:70]4=[O:71])[C:60]=3[C:61]=2[OH:66])[CH:56]=1.[NH2:90][CH2:91][CH:92]1[CH2:97][CH2:96][NH:95][CH2:94][CH2:93]1>CN(C=O)C>[OH:80][C:76]1[C:75]2[C:81](=[O:82])[C:83]([NH:90][CH2:91][CH:92]3[CH2:97][CH2:96][NH:95][CH2:94][CH2:93]3)=[CH:84][C:85](=[O:86])[C:74]=2[C:73]([OH:89])=[C:72]2[C:70](=[O:71])[C@:67]3([C:60]4[C:61]([OH:66])=[C:62]5[C:57]([CH:56]=[C:55](/[CH:54]=[CH:53]/[CH:52]=[CH:51]/[CH3:50])[NH:65][C:63]5=[O:64])=[CH:58][C:59]=4[CH2:69][CH2:68]3)[C:78](=[O:79])[C:77]=12

Participants

5

Reactant 3

HCID 235274-(Aminomethyl)piperidineHCID 178442045HCID 178442045, compoundHCID 178493331HCID 178493331, compound

Product 1

HCID 178442044HCID 178442044, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Ten (10) mg (18.6 μmol) fredericamycin are dissolved in 1 ml DMF under argon, then 2.7 PI (22.3 μmol) 4-aminomethylpiperidine are added at room temperature. The reaction mixture is concentrated at high vacuum until dry after 24 h.

Workup

  1. concentrationThe reaction mixture is concentrated at high vacuum
  2. customuntil dry after 24 h.

Sources & evidence

ORD record
ord-c311f3a61ffd4d4d8dd15f4f2c7f6cd0
Source dataset
uspto-grants-2012_08
Patent number
US08247424B2

Reaction notes

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