反应详情

温度

90 °C

A suspension of 5-tert-butoxycarbonylamino-2-chloro-isonicotinic acid (2.46 g) in aqueous 2N potassium hydroxide solution (45 mL) was stirred at 90° C. for 5 hours. After cooling to room temperature, the solution was acidified by slow addition of 6N hydrochloric acid. The formed precipitate was filtered off, washed with water, MTB-ether and hexane and dried in vacuum to afford 700 mg of the title compound of the formula

1. temperatureAfter cooling to room temperature
2. filtrationThe formed precipitate was filtered off
3. washwashed with water, MTB-ether and hexane
4. customdried in vacuum