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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 887777Generated: October 30, 2026

Hydrochloric Acid → 2-(2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochloride

https://huagongshe.com/reaction/887777

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactantethyl 9-(2-aminoethyl)-2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylateHCID 59145868—
Product2-(2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochlorideHCID 68701819—

Reaction Conditions

Temperature100 °C

Reaction Steps

A mixture of ethyl 9-(2-aminoethyl)-2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate (140 mg, 0.487 mmol) in 12M hydrochloric acid (5 mL) was stirred at 100° C. for 2 days, and concentrated under reduced pressure to give the title compound. The obtained title compound was used for the reaction of Example 18 without purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08247429B2
Source datasetuspto-grants-2012_08
ORD IDord-3d680b3ea20444e5b5da2c6d75f679d6
Source noteuspto-grants-2012_08