Hydrochloric Acid → 2-(2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochloride

HRID 887777Notes

Reaction equation

HRID 887777 reaction equation
[NH2:1][CH2:2][CH2:3][CH:4]1[C:8]2[C:9]3[N:10]([N:13]=[C:14]([CH3:21])[C:15]=3C(OCC)=O)[CH:11]=[CH:12][C:7]=2[CH2:6][CH2:5]1.[ClH:22]>>[ClH:22].[CH3:21][C:14]1[CH:15]=[C:9]2[C:8]3[CH:4]([CH2:3][CH2:2][NH2:1])[CH2:5][CH2:6][C:7]=3[CH:12]=[CH:11][N:10]2[N:13]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59145868ethyl 9-(2-aminoethyl)-2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate

Product 1

HCID 687018192-(2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridin-9-yl)ethanamine hydrochloride

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl 9-(2-aminoethyl)-2-methyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate (140 mg, 0.487 mmol) in 12M hydrochloric acid (5 mL) was stirred at 100° C. for 2 days, and concentrated under reduced pressure to give the title compound. The obtained title compound was used for the reaction of Example 18 without purification.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3d680b3ea20444e5b5da2c6d75f679d6
Source dataset
uspto-grants-2012_08
Patent number
US08247429B2

Reaction notes

Loading…