反应详情

温度

100 °C

Methyl 9-(2-aminoethyl)-2-phenyl-8,9-dihydro-7H-cyclopenta[c]pyrazolo[1,5-a]pyridine-1-carboxylate (295 mg, 0.881 mmol) was dissolved in 40% (v/v) sulfuric acid (6 mL), and the mixture was stirred at 100° C. for 3 days. The reaction solution was diluted with water and neutralized with sodium hydrogen carbonate, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound. The obtained title compound was used for the reaction of Example 34 without purification.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe extract was dried over anhydrous sodium sulfate
3. customThe solvent was evaporated under reduced pressure