Water → HCID 178467197, compound

HRID 887829Notes

Reaction equation

HRID 887829 reaction equation
Cl.Cl.[NH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][N:12]2[CH2:16][C@H:15]3[C:17]4[CH:18]=[C:19]([C:25]#[N:26])[CH:20]=[CH:21][C:22]=4[O:23][CH2:24][C@@H:14]3[CH2:13]2)[CH2:6][CH2:5]1.[CH3:27][CH2:28][O:29][C:30]1[C:34](=O)[C:32](=[O:33])[C:31]=1[O:36]CC.O>C(O)C>[CH2:28]([O:29][C:30]1[C:31](=[O:36])[C:32](=[O:33])[C:34]=1[NH:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][N:12]2[CH2:16][C@H:15]3[C:17]4[CH:18]=[C:19]([C:25]#[N:26])[CH:20]=[CH:21][C:22]=4[O:23][CH2:24][C@@H:14]3[CH2:13]2)[CH2:6][CH2:5]1)[CH3:27]

Participants

5

Reactant 3

HCID 962WaterHCID 123228Diethyl squarateHCID 178478680HCID 178478680, compound

Product 1

HCID 178467197HCID 178467197, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 g of the compound of Example 1 (6.15 mmol) and 0.9 ml of diethyl squarate are stirred at ambient temperature for 2 hours in 15 ml of ethanol. After adding water, the crystals obtained are filtered off and dried in a desiccator to yield the title product in the form of a white powder.

Workup

  1. customthe crystals obtained
  2. filtrationare filtered off
  3. customdried in a desiccator

Sources & evidence

ORD record
ord-fad967879c014c6b8cd024c8ef1aec99
Source dataset
uspto-grants-2012_08
Patent number
US08247441B2

Reaction notes

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