Ammonia → HCID 178479172, compound

HRID 887830Notes

Reaction equation

HRID 887830 reaction equation
C(O[C:4]1[C:7](=[O:8])[C:6](=[O:9])[C:5]=1[NH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([CH2:17][CH2:18][N:19]2[CH2:23][C@H:22]3[C:24]4[CH:25]=[C:26]([C:32]#[N:33])[CH:27]=[CH:28][C:29]=4[O:30][CH2:31][C@@H:21]3[CH2:20]2)[CH2:13][CH2:12]1)C.[NH3:34].[ClH:35]>C(O)C.C(#N)C>[ClH:35].[NH2:34][C:4]1[C:7](=[O:8])[C:6](=[O:9])[C:5]=1[NH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([CH2:17][CH2:18][N:19]2[CH2:23][C@H:22]3[C:24]4[CH:25]=[C:26]([C:32]#[N:33])[CH:27]=[CH:28][C:29]=4[O:30][CH2:31][C@@H:21]3[CH2:20]2)[CH2:13][CH2:12]1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 178467197HCID 178467197, compound

Product 1

HCID 178479172HCID 178479172, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 6342AcetonitrileSolvent

Procedure

A solution of 1.17 g of the compound obtained in Step A of Example 20 (2.61 mmol) in 13 ml of ethanol is treated with 13 ml of a saturated solution of ammonia in acetonitrile for 16 hours. The solid obtained is filtered off and then washed with ethyl acetate to finally yield, after converting to a salt in ethanol in the warm state using 1N ethereal HCl, the title product.

Workup

  1. customThe solid obtained
  2. filtrationis filtered off
  3. washwashed with ethyl acetate
  4. customto finally yield

Sources & evidence

ORD record
ord-4fe871cc2d5e4d38ad85e3d2b6e51163
Source dataset
uspto-grants-2012_08
Patent number
US08247441B2

Reaction notes

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