Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 887891Notes

Reaction equation

HRID 887891 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

Product 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, mixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and employed in stage b without further purification.

Workup

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customemployed in stage b without further purification

Sources & evidence

ORD record
ord-9117c9352e584eaf92331cbf464dca96
Source dataset
uspto-grants-2012_08
Patent number
US08247452B2

Reaction notes

Loading…