反应详情

温度

0 °C

41.1 g (0.3 mol) of 4-methoxy-2-methylphenylamine and 37 g (0.5 mol) of dimethylethylamine were dissolved in 50 ml of tetrahydrofuran, and 35.7 g (0.35 mol) of acetic anhydride were added while stirring. The solution heated to boiling during this. It was stirred at room temperature for 1 hour and cooled to 0° C. The resulting precipitate was filtered off with suction and washed several times with a little cold tetrahydrofuran and dried. 40 g (75%) of colorless crystals of the desired product were obtained.

1. temperatureThe solution heated
2. stirringIt was stirred at room temperature for 1 hour
3. filtrationThe resulting precipitate was filtered off with suction
4. washwashed several times with a little cold tetrahydrofuran
5. customdried