反应详情

7.5 g of 2-acetylamino-5-methoxy-4-nitrobenzoic acid (crude mixture from stage c) were heated to reflux in 50 ml of water and 20 ml of concentrated hydrochloric acid for 3 hours. The reaction mixture was concentrated in vacuo and purified by column chromatography (silica gel, dichloromethane/isopropanol=9/1). 3.1 g (50%) of the desired product were obtained.

1. concentrationThe reaction mixture was concentrated in vacuo
2. custompurified by column chromatography (silica gel, dichloromethane/isopropanol=9/1)