反应详情

120 mg (0.5 mmol) of 6-methoxy-7-nitro-1H-quinazoline-2,4-dione were taken up in a mixture of 5 ml of tetrahydrofuran, 5 ml of methanol and 5 ml of acetic acid and hydrogenated with palladium catalysis at room temperature for 3 hours. The reaction solution was heated to dissolve precipitated product and was filtered hot to remove the catalyst. The filtrate was concentrated and, after addition of toluene, again concentrated. 100 mg (100%) of the desired product were obtained.

1. temperatureThe reaction solution was heated
2. dissolutionto dissolve
3. customprecipitated product
4. filtrationwas filtered hot
5. customto remove the catalyst
6. concentrationThe filtrate was concentrated
7. additionafter addition of toluene
8. concentrationagain concentrated