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Alternatively, to the solution of mandelic acid amide in dichloromethane is added 50% aqueous caustic soda at RT. Subsequently p-toluene sulfonic acid chloride (1.0 equivalent) is added as a solution in dichloromethane keeping the temperature below 25° C. The biphasic reaction mixture is stirred at RT until a satisfactory conversion is reached, phases are separated, the aqueous phase is extracted once with dichloromethane and then the combined organic phases are washed with water. After a solvent switch to toluene the solution is concentrated, cooled to 5° C. and the precipitate filtered. The crystals are washed with cooled toluene and dried in vacuo at 40° C.

1. customThe biphasic reaction mixture
2. customphases are separated
3. extractionthe aqueous phase is extracted once with dichloromethane
4. washthe combined organic phases are washed with water
5. concentrationAfter a solvent switch to toluene the solution is concentrated
6. temperaturecooled to 5° C.
7. filtrationthe precipitate filtered
8. washThe crystals are washed with cooled toluene
9. customdried in vacuo at 40° C.