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HRID888004

反应详情

EQUATION

反应方程式

HRID 888004 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COc1cc2c(cc1OC)[C@H](CCc1ccc(C(F)(F)F)cc1)NCC2
HCID44133419

(1S)-6,7-Dimethoxy-1-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinoline

C20H22F3NO2

结构：CNC(=O)[C@@H](OS(=O)(=O)c1ccc(C)cc1)c1ccccc1
HCID57354974

(1S)-2-(Methylamino)-2-oxo-1-phenylethyl 4-methylbenzene-1-sulfonate

C16H17NO4S

PRODUCTS

生成物

1
结构：CNC(=O)[C@@H](c1ccccc1)N1CCc2cc(OC)c(OC)cc2[C@@H]1CCc1ccc(C(F)(F)F)cc1
HCID23727689

Almorexant

C29H31F3N2O3

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

2 次

结构：CC(=O)CC(C)C
溶剂HCID7909

4-Methyl-2-pentanone

C6H12O

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

To the solution of the compound 7 in MIBK are added 1.2 equivalents of the compound 6, 1.1 equivalents caustic soda and 1.1 equivalents potassium carbonate and heated to 70-90° C. Water is added and the mixture is heated at the same temperature for 0.5 to 3 hours and then cooled to RT. Alternatively, after full conversion the solution is cooled to RT and water is added. Phase separation is followed by a second washing of the organic phase with water and again phase separation.

WORKUP

后处理

  1. temperaturethe mixture is heated at the same temperature for 0.5 to 3 hours
  2. temperaturecooled to RT
  3. temperatureAlternatively, after full conversion the solution is cooled to RT
  4. customPhase separation
  5. washa second washing of the organic phase with water and again phase separation