1-Propanamine, 3-[2-(dimethylamino)ethoxy]- → HCID 68406402, compound

HRID 888012Notes

Reaction equation

[CH3:1][N:2]([CH2:4][CH2:5][O:6][CH2:7][CH2:8][CH2:9][NH2:10])[CH3:3].[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH:18][C:19](=[O:36])[C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][N:29]=[C:28](S(C)(=O)=O)[N:27]=2)=[CH:22][CH:21]=1>CN(C)C(=O)C>[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH:18][C:19](=[O:36])[C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][N:29]=[C:28]([NH:10][CH2:9][CH2:8][CH2:7][O:6][CH2:5][CH2:4][N:2]([CH3:3])[CH3:1])[N:27]=2)=[CH:22][CH:21]=1

Participants

Conditions

Temperature: 50 °C

Procedure

To a solution of dimethylaminoethoxypropylamine (2.02 mg, 12.5 μmol) in N,N-dimethylacetamide (125 μl), was added a solution of N-(2-aminophenyl)-4-[2-(methylsulfonyl)pyrimidin-4-yl]benzamide (Method 62, 2.2 mg, 5 mop in N,N-dimethylacetamide (100 μl). The reaction mixture was heated to 50° C. and agitated for a period of 16 hours, before being evaporated to dryness to give the title compound; Mass Spectrum: M+H+ 435.

Workup

custombefore being evaporated to dryness

Sources & evidence

ORD record: ord-9b2f1e4731844678a8785a10511dabd8
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08247562B2

Reaction notes

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