Hydrochloric Acid → HCID 68408114, compound

HRID 888025Notes

Reaction equation

HRID 888025 reaction equation
C(O[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:13][C:14](=[O:37])[C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:26]=[C:25]([CH2:27][CH2:28][CH2:29][NH:30][N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[N:24]=[CH:23][CH:22]=2)=[CH:17][CH:16]=1)(C)(C)C.[ClH:38]>O1CCOCC1.C(OCC)C>[ClH:38].[ClH:38].[ClH:38].[NH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH:13][C:14](=[O:37])[C:15]1[CH:20]=[CH:19][C:18]([C:21]2[N:26]=[C:25]([CH2:27][CH2:28][CH2:29][NH:30][N:31]3[CH2:36][CH2:35][O:34][CH2:33][CH2:32]3)[N:24]=[CH:23][CH:22]=2)=[CH:17][CH:16]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86599909HCID 86599909, compound

Product 1

HCID 68408114HCID 68408114, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

N-(2-t-Butoxyaminophenyl)-4-[2-(3-morpholinoaminopropyl)-pyrimidin-6-yl]benzamide (Method 20, 64 mg, 0.120 mmol) was suspended in 1,4 dioxane (1.5 ml) and a 4M solution of hydrogen chloride in 1,4-dioxane (1 ml) added. The reaction mixture was stirred at ambient temperature for 64 hours. The reaction mixture was diluted with diethyl ether, and the resultant precipitate was collected by filtration, washed with diethyl ether and air dried, to yield the title compound (as its hydrochloride salt) as an off white solid (62 mg, 95%); Mass Spectrum: M+H+ 433.

Workup

  1. filtrationthe resultant precipitate was collected by filtration
  2. washwashed with diethyl ether and air
  3. customdried

Sources & evidence

ORD record
ord-8a2e32faf8de4b33a7bfaee4dde2151e
Source dataset
uspto-grants-2012_08
Patent number
US08247562B2

Reaction notes

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