N-(tert-Butoxycarbonyl)-1,2-phenylenediamine → HCID 68407867, compound

HRID 888040Notes

Reaction equation

HRID 888040 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[CH:19][C:18]=1[F:26]>>[Br:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:15][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:22])=[CH:19][C:18]=1[F:26]

Participants

3

Reactant 2

HCID 676311N-(tert-Butoxycarbonyl)-1,2-phenylenediamineHCID 27733414-Bromo-3-fluorobenzoic acid

Product 1

HCID 68407867HCID 68407867, compound

Procedure

1-(N-t-butoxycarbonylamino)-2-aminobenzene (Method 17, 1.25 g, 6 mmol) was reacted with 4-bromo-3-fluorobenzoic acid (1.1 g, 5.0 mmol) in an analogous manner to that described in Method 16 to give the title compound, which was used without further purification; Mass Spectrum: (M+H+-Boc) 311.

Sources & evidence

ORD record
ord-7313a6f0440b42e58eca30b89bb6867b
Source dataset
uspto-grants-2012_08
Patent number
US08247562B2

Reaction notes

Loading…