Chloride → HCID 86621105, compound

HRID 888053Notes

Reaction equation

HRID 888053 reaction equation
O[CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1.[Cl-:18]>>[Cl:18][CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 312ChlorideHCID 22340602Butanoic acid, 4-[4-(hydroxymethyl)phenoxy]-, ethyl ester

Product 1

HCID 86621105HCID 86621105, compound

Procedure

Ethyl 4-(4-(chloromethyl)phenoxy)butanoate 13i was prepared from 29b according to the protocol described for the compound 13h in Example 26 (Scheme 9). The title chloride 13i was isolated as colorless oil in 96% yield (1.25 g). 1H NMR (400 MHz, CDCl3): δ 1.24 (3H, t, J=7.2 Hz); 2.06 (2H, m); 2.18 (2H, t, J=7.2 Hz)); 4.00 (2H, t, J=6.4 Hz); 4.14 (2H, q, J=7.2 Hz); 4.54 (2H, s); 6.83 (1H, s); 6.86 (1H, s); 7.27 (1H, m); 7.29 (1H, s). MS (ESI): m/z=258.10 (M+H+).

Sources & evidence

ORD record
ord-130013904c5a41fdbaf04d22947d3eb7
Source dataset
uspto-grants-2012_08
Patent number
US08247563B2

Reaction notes

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