HCID 22249227, compound → tert-Butyl 4-(5-amino-2-(perfluoroethyl)benzyl)piperazine-1-carboxylate

HRID 888082Notes

Reaction equation

HRID 888082 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[C:19]([N+:21]([O-])=O)[CH:18]=[CH:17][C:16]=2[C:24]([F:30])([F:29])[C:25]([F:28])([F:27])[F:26])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].FC(F)(C1C=CC(N)=CC=1OCCN1CCCC1)C(F)(F)F>>[NH2:21][C:19]1[CH:18]=[CH:17][C:16]([C:24]([F:29])([F:30])[C:25]([F:26])([F:27])[F:28])=[C:15]([CH:20]=1)[CH2:14][N:11]1[CH2:10][CH2:9][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 22249227HCID 22249227, compoundHCID 860022324-Pentafluoroethyl-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamine

Product 1

HCID 86614208tert-Butyl 4-(5-amino-2-(perfluoroethyl)benzyl)piperazine-1-carboxylate

Procedure

tert-Butyl 4-(5-amino-2-(perfluoroethyl)benzyl)piperazine-1-carboxylate was prepared from 1-Boc-4-(5-nitro-2-pentafluoroethyl-benzyl)-piperazine similar to that described in the preparation of 4-pentafluoroethyl-3-(2-pyrrolidin-1-yl-ethoxy)-phenylamine.

Sources & evidence

ORD record
ord-eb2e6dd462764447b8ee309c8ece36dd
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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