反应详情

5-Nitrobenzo[d]thiazole (150 mg) was dissolved in THF (20 mL) at 0° C. and AcOH (1 mL) was added followed by Zinc dust (1.65 g). Mixture was stirred at RT for 1 h and was filtered on silica pad (rinsed with EtOAc). Solvent was evaporated, residue was diluted with NaHCO3 and extracted with EtOAc. Organic phases was dried, filtered and evaporated to give benzo[d]thiazol-5-amine.

1. filtrationwas filtered on silica pad (rinsed with EtOAc)
2. customSolvent was evaporated
3. additionresidue was diluted with NaHCO3
4. extractionextracted with EtOAc
5. customOrganic phases was dried
6. filtrationfiltered
7. customevaporated