N-(2-acetyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-fluoro-nicotinamide → N-(2-Acetyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide

HRID 888135Notes

Reaction equation

HRID 888135 reaction equation
[C:1]([N:4]1[CH2:13][C:12]([CH3:15])([CH3:14])[C:11]2[C:6](=[CH:7][C:8]([NH:16][C:17](=[O:25])[C:18]3[CH:23]=[CH:22][CH:21]=[N:20][C:19]=3F)=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].Cl.Cl.[NH:28]1[C:32]2=[N:33][C:34]([CH2:37][NH2:38])=[CH:35][CH:36]=[C:31]2[CH:30]=[CH:29]1>>[C:1]([N:4]1[CH2:13][C:12]([CH3:15])([CH3:14])[C:11]2[C:6](=[CH:7][C:8]([NH:16][C:17](=[O:25])[C:18]3[CH:23]=[CH:22][CH:21]=[N:20][C:19]=3[NH:38][CH2:37][C:34]3[N:33]=[C:32]4[NH:28][CH:29]=[CH:30][C:31]4=[CH:36][CH:35]=3)=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 21959589N-(2-acetyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-fluoro-nicotinamideHCID 692647382225154-13-0

Product 1

HCID 16225620N-(2-Acetyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide

Procedure

The titled compound was prepared from N-(2-acetyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-fluoro-nicotinamide and C-(1H-pyrrolo[2,3-b]pyridin-6-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 469 (M+H). Calc'd. for C27H28N6O2—468.56.

Sources & evidence

ORD record
ord-69887727fe7344c585730a8617bcb521
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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