N-(2-acetyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-fluoro-nicotinamide → N-(2-Acetyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	N-(2-acetyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-fluoro-nicotinamide	HCID 21959589	—
Reactant	2225154-13-0	HCID 69264738	—
Product	N-(2-Acetyl-4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide	HCID 16225620	—

Reaction Steps

The titled compound was prepared from N-(2-acetyl-4,4-dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-fluoro-nicotinamide and C-(1H-pyrrolo[2,3-b]pyridin-6-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 469 (M+H). Calc'd. for C27H28N6O2—468.56.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247556B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-69887727fe7344c585730a8617bcb521
Source note	uspto-grants-2012_08