N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide → N-(4,4-Dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

HRID 888140Notes

Reaction equation

HRID 888140 reaction equation
[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:21])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][C:15]=3F)=[CH:9][CH:10]=2)[NH:5][CH2:4][CH2:3]1.Cl.Cl.[NH:25]1[C:29]2=[N:30][CH:31]=[CH:32][C:33]([CH2:34][NH2:35])=[C:28]2[CH:27]=[CH:26]1>>[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:21])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][C:15]=3[NH:35][CH2:34][C:33]3[CH:32]=[CH:31][N:30]=[C:29]4[NH:25][CH:26]=[CH:27][C:28]=34)=[CH:9][CH:10]=2)[NH:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 68908856N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamideHCID 69263704(1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochloride

Product 1

HCID 58942005N-(4,4-Dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

Procedure

The titled compound was prepared from N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide and C-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 427 (M+H). Calc'd. for C25H26N6O—426.52.

Sources & evidence

ORD record
ord-71c2b2445fba460ba9ff8c03bc7edf58
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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