N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide → N-(4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

HRID 888141Notes

Reaction equation

HRID 888141 reaction equation
[CH3:1][C:2]1([CH3:23])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:21])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][C:15]=3F)=[CH:9][CH:10]=2)[NH:5][C:4](=[O:22])[CH2:3]1.Cl.Cl.[NH:26]1[C:30]2=[N:31][CH:32]=[CH:33][C:34]([CH2:35][NH2:36])=[C:29]2[CH:28]=[CH:27]1>>[CH3:1][C:2]1([CH3:23])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:21])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][C:15]=3[NH:36][CH2:35][C:34]3[CH:33]=[CH:32][N:31]=[C:30]4[NH:26][CH:27]=[CH:28][C:29]=34)=[CH:9][CH:10]=2)[NH:5][C:4](=[O:22])[CH2:3]1

Participants

3

Reactant 2

HCID 21961472N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamideHCID 69263704(1h-Pyrrolo[2,3-b]pyridin-4-yl)methanamine dihydrochloride

Product 1

HCID 58941984N-(4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)-2-[(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide

Procedure

The titled compound was prepared from N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide and C-(1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 441 (M+H). Calc'd. for C25H24N6O2—440.51.

Sources & evidence

ORD record
ord-f0c62ea340624e4b9a49d144843b8990
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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