N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide → 2-[(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]-N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

HRID 888155Notes

Reaction equation

HRID 888155 reaction equation
[CH3:1][C:2]1([CH3:23])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:21])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][C:15]=3F)=[CH:9][CH:10]=2)[NH:5][C:4](=[O:22])[CH2:3]1.Cl.Cl.[NH:26]1[C:30]2=[N:31][CH:32]=[CH:33][C:34]([CH2:35][NH2:36])=[C:29]2[CH2:28][CH2:27]1>>[NH:26]1[C:30]2=[N:31][CH:32]=[CH:33][C:34]([CH2:35][NH:36][C:15]3[N:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13]([NH:12][C:8]3[CH:7]=[C:6]4[C:11]([C:2]([CH3:23])([CH3:1])[CH2:3][C:4](=[O:22])[NH:5]4)=[CH:10][CH:9]=3)=[O:21])=[C:29]2[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 21961472N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamideHCID 69263942C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride

Product 1

HCID 162254222-[(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]-N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

Procedure

The titled compound was prepared from N-(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide and C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 437 (M+H). Calc'd. for C25H26N6O2—442.52.

Sources & evidence

ORD record
ord-c953c2bdbbfe4bf3b9aac297ad71ee89
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

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