N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide → 2-[(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]-N-(4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

HRID 888156Notes

Reaction equation

HRID 888156 reaction equation
[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([NH:12][C:13](=[O:21])[C:14]3[CH:19]=[CH:18][CH:17]=[N:16][C:15]=3F)=[CH:9][CH:10]=2)[NH:5][CH2:4][CH2:3]1.Cl.Cl.[NH:25]1[C:29]2=[N:30][CH:31]=[CH:32][C:33]([CH2:34][NH2:35])=[C:28]2[CH2:27][CH2:26]1>>[NH:25]1[C:29]2=[N:30][CH:31]=[CH:32][C:33]([CH2:34][NH:35][C:15]3[N:16]=[CH:17][CH:18]=[CH:19][C:14]=3[C:13]([NH:12][C:8]3[CH:7]=[C:6]4[C:11]([C:2]([CH3:22])([CH3:1])[CH2:3][CH2:4][NH:5]4)=[CH:10][CH:9]=3)=[O:21])=[C:28]2[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 68908856N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamideHCID 69263942C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride

Product 1

HCID 162246172-[(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]-N-(4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)nicotinamide

Procedure

The titled compound was prepared from N-(4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-7-yl)-2-fluoro-nicotinamide and C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 429 (M+H). Calc'd. for C25H28N6O—428.54.

Sources & evidence

ORD record
ord-b4767d56b415424f8b578d92cb86f65b
Source dataset
uspto-grants-2012_08
Patent number
US08247556B2

Reaction notes

Loading…