(3R)-3-methyl-1-pyridin-2-ylpiperazine → (3S)-3-methyl-1-pyridin-2-ylpiperazine

HRID 888171Notes

Reaction equation

HRID 888171 reaction equation
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:3]1.C[C@H]1CNCCN1>CO.C(Cl)(Cl)Cl>[CH3:1][C@@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 1519493(3R)-3-methyl-1-pyridin-2-ylpiperazineHCID 27342192-Methylpiperazine, (S)-

Product 1

HCID 1519492(3S)-3-methyl-1-pyridin-2-ylpiperazine

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

The title compound was prepared following the protocol used for the preparation of Intermediate 3, but starting from (S)-2-methyl piperazine (43%). TLC-Chloroform/MeOH (8/2); Rf=0.2.

Sources & evidence

ORD record
ord-670aadbaf3eb4fbcbaed95bc018bbae5
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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