2-Bromopyrimidine → HCID 67331487, compound

HRID 888175Notes

Reaction equation

HRID 888175 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.[Br:8][C:9]1[N:14]=[CH:13][CH:12]=[CH:11][N:10]=1>C1(C)C(C)=CC=CC=1>[BrH:8].[CH3:1][C@@H:2]1[NH:3][CH2:4][CH2:5][N:6]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 783452-BromopyrimidineHCID 27342192-Methylpiperazine, (S)-

Product 1

HCID 67331487HCID 67331487, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

To a solution of (S)-2-methyl piperazine (4.0 g, 40.0 mmol) in xylene (100 mL) at 140° C. under nitrogen was added 2-bromopyrimidine (6.36 g, 40.0 mmol) slowly over a period of 30 min. The heating was continued for additional 15 h and cooled. The solid precipitated was filtered and dried under suction to afford the title compound (4 g, 40%). TLC-Chloroform/MeOH (8/2); Rf: 0.15.

Workup

  1. temperaturecooled
  2. customThe solid precipitated
  3. filtrationwas filtered
  4. customdried under suction

Sources & evidence

ORD record
ord-28769a0ebcd844efbaa8c22f3d3dd5f7
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

Loading…