2-Chloro-4-(trifluoromethyl)pyridine → HCID 58488037, compound

HRID 888176Notes

Reaction equation

HRID 888176 reaction equation
[CH3:1][C@@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.Cl[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][N:10]=1>C1(C)C(C)=CC=CC=1>[CH3:1][C@H:2]1[NH:3][CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][N:10]=2)[CH2:7]1

Participants

4

Reactant 2

HCID 1449582-Chloro-4-(trifluoromethyl)pyridineHCID 73304342-Methylpiperazine, (R)-

Product 1

HCID 58488037HCID 58488037, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

To a solution of (R)-2-methyl piperazine (4.0 g, 40 mmol) in xylene (100 mL) at 140° C. under nitrogen was added 2-chloro-4-trifluoromethylpyridine (726 g, 40.0 mmol) slowly over a period of 30 min. The heating was continued for additional 12 h and cooled. The reaction mixture was evaporated to a residue and the residue was purified by chromatography using chloroform/methanol (8/2) as eluent to afford of the title compound as a liquid (3.5 g, 36%). TLC-Chloroform/MeOH (8/2); Rf: 0.25.

Workup

  1. temperaturecooled
  2. customThe reaction mixture was evaporated to a residue
  3. customthe residue was purified by chromatography

Sources & evidence

ORD record
ord-006d35bd6f734f0abb707f2e13ec9957
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

Loading…