Hydrochloric Acid → 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochloride

HRID 888180Notes

Reaction equation

HRID 888180 reaction equation
[C:1]1([C:7]2[O:11][N:10]=[C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:25]>CCOCC>[ClH:25].[ClH:25].[C:1]1([C:7]2[O:11][N:10]=[C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11992900Tert-butyl 4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate

Product 1

HCID 673331091-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochlorideYield 93%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of tert-butyl 4-(5-phenyl-1,2,4-oxadiazol-3-yl)piperazine-1-carboxylate (5 g) in a 2M solution of HCl in ether (100 mL) was stirred at RT for 6 hours. The solvent was removed under vacuum to afford 4.3 g (93%) of the title compound as a solid. TLC-Chloroform/methanol (8/2): Rf=0.2. HPLC purity: 97%.

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-90846471813c46d8ae484b5791a9f9c3
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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