2,5-Dibromopyridine → 1-(5-Bromopyridin-2-yl)piperazine

HRID 888185Notes

Reaction equation

HRID 888185 reaction equation
C[C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[CH:13]=[CH:12][C:11](C(F)(F)F)=[CH:10][N:9]=2)[CH2:3]1.[Br:18]C1C=CC(Br)=CN=1>>[Br:18][C:11]1[CH:12]=[CH:13][C:8]([N:4]2[CH2:5][CH2:6][NH:7][CH2:2][CH2:3]2)=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 693532,5-DibromopyridineHCID 26597358(3R)-3-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperazine

Product 1

HCID 164142271-(5-Bromopyridin-2-yl)piperazineYield 73%

Procedure

The title compound was prepared following the procedure of the Intermediate 15, but starting from 2,5-dibromopyridine. Purification by chromatography (DCM/MeOH 80/20) gave the title compound as a brown powder (73%). M+(ESI): 244.2. HPLC (Condition A), Rt: 1.1 min (HPLC purity: 79.7%).

Workup

  1. customThe title compound was prepared
  2. customPurification by chromatography (DCM/MeOH 80/20)

Sources & evidence

ORD record
ord-b81932b8b59b48318db966b7179a33de
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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