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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 888185Generated: October 27, 2026

2,5-Dibromopyridine → 1-(5-Bromopyridin-2-yl)piperazine

https://huagongshe.com/reaction/888185

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,5-DibromopyridineHCID 69353—
Reactant(3R)-3-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]piperazineHCID 26597358—
Product1-(5-Bromopyridin-2-yl)piperazineHCID 1641422773%

Reaction Steps

The title compound was prepared following the procedure of the Intermediate 15, but starting from 2,5-dibromopyridine. Purification by chromatography (DCM/MeOH 80/20) gave the title compound as a brown powder (73%). M+(ESI): 244.2. HPLC (Condition A), Rt: 1.1 min (HPLC purity: 79.7%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08247437B2
Source datasetuspto-grants-2012_08
ORD IDord-b81932b8b59b48318db966b7179a33de
Source noteuspto-grants-2012_08