HCID 10612278, compound → HCID 58487999, compound

HRID 888188Notes

Reaction equation

HRID 888188 reaction equation
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4](C2C=CC(CCC)=CC=2)[CH2:3]1.Br[C:18]1[CH:23]=[CH:22][C:21]([C:24]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[O:26][CH:25]=2)=[CH:20][CH:19]=1>>[O:26]1[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:24]([C:21]2[CH:22]=[CH:23][C:18]([N:4]3[CH2:5][CH2:6][NH:7][C@H:2]([CH3:1])[CH2:3]3)=[CH:19][CH:20]=2)=[CH:25]1

Participants

3

Reactant 2

HCID 10612278HCID 10612278, compoundHCID 58487948HCID 58487948, compound

Product 1

HCID 58487999HCID 58487999, compoundYield 21%

Procedure

The title compound was prepared following the procedure of Intermediate 17, but starting from 3-(4-bromophenyl)-1-benzofuran (obtained as described in Malamas et al., 2000, J. Med. Chem., 43, 1293-1310). Purification by chromatography (DCM/MeOH 80/20) afforded the title compound as beige solid (21%). HPLC (Condition A), Rt: 3.0 min (HPLC purity: 93.4%). M+(ESI): 293.2

Workup

  1. customThe title compound was prepared
  2. customPurification by chromatography (DCM/MeOH 80/20)

Sources & evidence

ORD record
ord-2976cd667496460fa57d28998b413496
Source dataset
uspto-grants-2012_08
Patent number
US08247437B2

Reaction notes

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