1-Bromo-3,4-(methylenedioxy)benzene → (3R)-1-(1,3-benzodioxol-5-yl)-3-methylpiperazine

Participants

Role	Name	HCID	Charge
Reactant	1-Bromo-3,4-(methylenedioxy)benzene	HCID 75831	—
Reactant	(3R)-1-(3,4-dimethoxyphenyl)-3-methylpiperazine	HCID 58487959	—
Product	(3R)-1-(1,3-benzodioxol-5-yl)-3-methylpiperazine	HCID 11687200	—

Reaction Steps

The title compound was prepared following the procedure of Intermediate 25, but starting from 4-bromo-1,2-(methylenedioxy)benzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a yellow oil. M+(ESI): 221.2. HPLC (Condition A), Rt: 1.3 min (HPLC purity: 100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08247437B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-4d73cd94ed4348849786c0c5ee49a0fd
Source note	uspto-grants-2012_08