Hydrochloric Acid → HCID 68498763, compound

HRID 888366Notes

Reaction equation

HRID 888366 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:18]=[C:19]([CH:21]([OH:26])[C:22]([F:25])([F:24])[F:23])[CH:20]=2)[C:11]([O:13]C(C)(C)C)=[O:12])=[N:6][CH:7]=1.Cl>ClCCl>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:18]=[C:19]([CH:21]([OH:26])[C:22]([F:25])([F:23])[F:24])[CH:20]=2)[C:11]([OH:13])=[O:12])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68500334Tert-butyl 3-(5-methylpyridin-2-yl)-5-(2,2,2-trifluoro-1-hydroxyethyl)benzoate

Product 1

HCID 68498763HCID 68498763, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 3-(5-methylpyridin-2-yl)-5-(2,2,2-trifluoro-1-hydroxyethyl)benzoate (3.25 g, 8.85 mmol) in dichloromethane (15 mL) was added hydrogen chloride (4.0 M in dioxane; 11.1 mL, 44.2 mmol). The reaction mixture was stirred at ambient temperature. After 18 h, the mixture was concentrated. Dichloromethane was added the suspension was filtered. The solid cake was washed with dihchloromethane and dried under reduced pressure to give the hydrochloride salt of the title compound. MS 312.1 (M+1).

Workup

  1. concentrationthe mixture was concentrated
  2. additionDichloromethane was added the suspension
  3. filtrationwas filtered
  4. washThe solid cake was washed with dihchloromethane
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-1204220c54f044c99d0591fc35a1a368
Source dataset
uspto-grants-2012_08
Patent number
US08247401B2

Reaction notes

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