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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 888367Generated: October 29, 2026

Trifluoroacetic acid → HCID 68500068, compound

https://huagongshe.com/reaction/888367

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 68499410HCID 68499410—
SolventDichloromethaneHCID 6344—
ProductHCID 68500068HCID 68500068—

Reaction Steps

To a DCM (22 mL) solution tert-butyl 4′-methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)biphenyl-3-carboxylate (1.6 g, 4.4 mmol) from step A was added trifluoroacetic acid (22 mL). The mixture was stirred at rt for 3 h and concentrated to dryness. The crude title compound was used in step C without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08247401B2
Source datasetuspto-grants-2012_08
ORD IDord-a5c9e3bae91a4826835e10116b13f0e5
Source noteuspto-grants-2012_08