Trifluoroacetic acid → HCID 68500068, compound

HRID 888367Notes

Reaction equation

HRID 888367 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]([OH:19])[C:15]([F:18])([F:17])[F:16])[CH:11]=[C:10]([C:20]([O:22]C(C)(C)C)=[O:21])[CH:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([CH:14]([OH:19])[C:15]([F:17])([F:18])[F:16])[CH:11]=[C:10]([C:20]([OH:22])=[O:21])[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68499410HCID 68499410, compound

Product 1

HCID 68500068HCID 68500068, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a DCM (22 mL) solution tert-butyl 4′-methyl-5-(2,2,2-trifluoro-1-hydroxyethyl)biphenyl-3-carboxylate (1.6 g, 4.4 mmol) from step A was added trifluoroacetic acid (22 mL). The mixture was stirred at rt for 3 h and concentrated to dryness. The crude title compound was used in step C without further purification.

Workup

  1. concentrationconcentrated to dryness
  2. customThe crude title compound was used in step C without further purification

Sources & evidence

ORD record
ord-a5c9e3bae91a4826835e10116b13f0e5
Source dataset
uspto-grants-2012_08
Patent number
US08247401B2

Reaction notes

Loading…