HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl methyl 5-(5-methylpyridin-2-yl)isophthalate | HCID 68499855 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetic acid | HCID 6422 | — |
| Product | 3-(Methoxycarbonyl)-5-(5-methylpyridin-2-yl)benzoic acid | HCID 68499417 | — |
Reaction Steps
To a solution of tert-butyl methyl 5-(5-methylpyridin-2-yl)isophthalate in dichloromethane (75 mL) was added 25 mL of trifluoroacetic acid. After 16 h, the reaction was concentrated and dried under vacuum to give TFA salt of the title compound (6.5 g). MS 272.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08247401B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-ea1ada1909f640bc8d7b2de2c47a53ca |
| Source note | uspto-grants-2012_08 |