Trifluoroacetic acid → Trifluoroacetic acid

HRID 888380Notes

Reaction equation

HRID 888380 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([C:21]([O:23][CH3:24])=[O:22])[CH:11]=[C:12]([CH:20]=2)[C:13]([O:15]C(C)(C)C)=[O:14])=[N:6][CH:7]=1.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[C:27]([OH:29])([C:26]([F:31])([F:30])[F:25])=[O:28].[CH3:24][O:23][C:21]([C:10]1[CH:11]=[C:12]([CH:20]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)[CH:9]=1)[C:13]([OH:15])=[O:14])=[O:22]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68499855tert-Butyl methyl 5-(5-methylpyridin-2-yl)isophthalate

Product 2

HCID 6422Trifluoroacetic acidHCID 684994173-(Methoxycarbonyl)-5-(5-methylpyridin-2-yl)benzoic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl methyl 5-(5-methylpyridin-2-yl)isophthalate in dichloromethane (75 mL) was added 25 mL of trifluoroacetic acid. After 16 h, the reaction was concentrated and dried under vacuum to give TFA salt of the title compound (6.5 g). MS 272.1 (M+1).

Workup

  1. concentrationthe reaction was concentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-ea1ada1909f640bc8d7b2de2c47a53ca
Source dataset
uspto-grants-2012_08
Patent number
US08247401B2

Reaction notes

Loading…